Background: Actinic keratoses (AKs), defined as carcinoma in situ of squamous carcinoma, is usually induced by excessive sun exposure. The efficacy of 3% diclofenac in 2.5% hyaluronic acid gel for treatment of AKs has been documented in a few studies.
Objective: Is diclofenac safe and effective for the management and treatment of AKs?
Method: All the papers that were cited in Medline and ISI Web of Science are included in this study.
Results/conclusion: The use of diclofenac is associated with a few side effects, which include pruritus, rashes, dry skin, and scaling. These side effects are usually minimal and tolerable; therefore, this topical medication is suggested as the first line of treatment for AKs.