Seizures following picornavirus infection

Epilepsia. 2008 Jun;49(6):1066-74. doi: 10.1111/j.1528-1167.2008.01535.x. Epub 2008 Mar 6.


Purpose: We demonstrate the establishment and characterization of a novel virus infection-induced seizure model in C57BL/6 mice.

Methods: C57BL/6 mice were infected with Theiler's murine encephalomyelitis virus (TMEV) or mock infected. Mice were followed for seizures, weight change, body temperature, motor function (righting reflex, rotorod) and neurological manifestations (inflammation [perivascular cuffing], pyknotic neurons, transforming growth factor [TGF]-beta expression).

Results: C57BL/6 mice are susceptible to seizures induced by TMEV infection. Approximately 50% of C57BL/6 mice develop transient afebrile seizures. Motor function and coordination are impaired in seized mice. Pyramidal neuron pyknosis and TGF-beta expression correlate with seizure activity in the hippocampus.

Discussion: The characterization of this model will enable the investigation of viral and immune contributions in the central nervous system to the development of seizure disorders in humans.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / pathology
  • Cardiovirus Infections / complications*
  • Cardiovirus Infections / pathology
  • Epilepsy, Tonic-Clonic / etiology*
  • Epilepsy, Tonic-Clonic / pathology
  • Female
  • Hippocampus / pathology
  • Immunoenzyme Techniques
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Motor Skills / physiology
  • Neurons / pathology
  • Postural Balance / physiology
  • Reflex / physiology
  • Seizures / etiology*
  • Seizures / pathology
  • Theilovirus*
  • Transforming Growth Factor beta / analysis


  • Transforming Growth Factor beta