The MTP -493TT genotype is associated with peripheral arterial disease: results from the Linz Peripheral Arterial Disease (LIPAD) Study

Clin Biochem. 2008 Jun;41(9):712-6. doi: 10.1016/j.clinbiochem.2008.02.007. Epub 2008 Feb 21.


Objectives: Microsomal triglyceride transfer protein (MTP) transfers lipids into apoprotein B-containing lipoproteins for secretion from liver, intestine, and heart. We hypothesized the -493T single nucleotide polymorphism in the MTP promoter region to be associated with altered lipoprotein levels and with presence of peripheral arterial disease (PAD).

Design and methods: 433 patients with symptomatic PAD and 433 controls matched for sex and age from the Linz Peripheral Arterial Disease (LIPAD) study were genotyped cross-sectionally for the -493T single nucleotide polymorphism in the promoter region of the MTP gene.

Results: The frequency of the -493T allele in patients with PAD was 0.320, whereas it was 0.255 in controls (p<0.001). The MTP -493TT genotype was independently associated with PAD, even after adjustment for LDL cholesterol. The odds ratio of the -493TT MTP genotype for PAD was 3.18 (95% CI, 1.76-5.71) when adjusted for current smoking, arterial hypertension, LDL cholesterol, triglycerides, glycohemoglobin, C-reactive protein, and homocysteine. Furthermore, we found an association between the MTP promoter polymorphism and the apolipoprotein B-containing lipoproteins total-cholesterol (p=0.011), LDL cholesterol (p=0.002) and apolipoprotein B (p=0.034).

Conclusions: Our results provide preliminary evidence for a potential role of the MTP -493TT genotype in the pathogenesis of PAD.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Carrier Proteins / blood
  • Carrier Proteins / genetics*
  • Cross-Sectional Studies
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Peripheral Vascular Diseases / blood
  • Peripheral Vascular Diseases / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Promoter Regions, Genetic
  • Risk Factors


  • Carrier Proteins
  • microsomal triglyceride transfer protein