Purine-containing cucurbitane triterpenoids from Cucurbita pepo cv dayangua

Phytochemistry. 2008 Apr;69(6):1434-8. doi: 10.1016/j.phytochem.2008.01.019. Epub 2008 Mar 5.

Abstract

Phytochemical investigation of the fruits of Cucurbita pepo cv dayangua led to the isolation of cucurbitaglycosides A (1) and B (2). This is the first report of cucurbitane triterpenoids with a purine unit. Their structures were elucidated mainly based on interpretation of HRESIMS results, as well as 1D and 2D NMR spectra. Cucurbitaglycosides A and B showed cytotoxic activity against the human epithelial carcinoma cell line HeLa with IC50 of 17.2 and 28.4 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cucurbita / chemistry*
  • Fruit / chemistry
  • Glycosides / chemistry
  • Glycosides / pharmacology
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Molecular Structure
  • Purines / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Purines
  • Triterpenes
  • cucurbitane