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. 2008 Mar;87(3):627-37.
doi: 10.1093/ajcn/87.3.627.

Glycemic Index, Glycemic Load, and Chronic Disease Risk--A Meta-Analysis of Observational Studies


Glycemic Index, Glycemic Load, and Chronic Disease Risk--A Meta-Analysis of Observational Studies

Alan W Barclay et al. Am J Clin Nutr. .


Background: Inconsistent findings from observational studies have prolonged the controversy over the effects of dietary glycemic index (GI) and glycemic load (GL) on the risk of certain chronic diseases.

Objective: The objective was to evaluate the association between GI, GL, and chronic disease risk with the use of meta-analysis techniques.

Design: A systematic review of published reports identified a total of 37 prospective cohort studies of GI and GL and chronic disease risk. Studies were stratified further according to the validity of the tools used to assess dietary intake. Rate ratios (RRs) were estimated in a Cox proportional hazards model and combined by using a random-effects model.

Results: From 4 to 20 y of follow-up across studies, a total of 40 129 incident cases were identified. For the comparison between the highest and lowest quantiles of GI and GL, significant positive associations were found in fully adjusted models of validated studies for type 2 diabetes (GI RR = 1.40, 95% CI: 1.23, 1.59; GL RR = 1.27, 95% CI: 1.12, 1.45), coronary heart disease (GI RR = 1.25, 95% CI: 1.00, 1.56), gallbladder disease (GI RR = 1.26, 95% CI: 1.13, 1.40; GL RR = 1.41, 95% CI: 1.25, 1.60), breast cancer (GI RR = 1.08, 95% CI: 1.02, 1.16), and all diseases combined (GI RR = 1.14, 95% CI: 1.09, 1.19; GL RR = 1.09, 95% CI: 1.04, 1.15).

Conclusions: Low-GI and/or low-GL diets are independently associated with a reduced risk of certain chronic diseases. In diabetes and heart disease, the protection is comparable with that seen for whole grain and high fiber intakes. The findings support the hypothesis that higher postprandial glycemia is a universal mechanism for disease progression.

Comment in

  • Glycemic index, glycemic load, and chronic disease risk.
    Mulholland HG, Murray LJ, Cantwell MM. Mulholland HG, et al. Am J Clin Nutr. 2008 Aug;88(2):475-6; author reply 476-7. doi: 10.1093/ajcn/88.2.475. Am J Clin Nutr. 2008. PMID: 18689385 No abstract available.
  • Bold conclusions from inadequate evidence.
    Tuomainen TP, Mursu J, Voutilainen S. Tuomainen TP, et al. Am J Clin Nutr. 2008 Aug;88(2):477-8; author reply 478-9. doi: 10.1093/ajcn/88.2.477. Am J Clin Nutr. 2008. PMID: 18689386 No abstract available.

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