N-Heterocyclic carbene catalysed beta-lactam synthesis

Org Biomol Chem. 2008 Mar 21;6(6):1108-13. doi: 10.1039/b800857b. Epub 2008 Feb 12.

Abstract

N-Heterocyclic carbenes promote the formal [2+2] cycloaddition of ketenes with N-tosyl imines to give the corresponding beta-lactams in good to excellent isolated yields; chiral NHCs give beta-lactams in high e.e. after crystallisation.