Metabolic programming in the immediate postnatal period

Trends Endocrinol Metab. May-Jun 2008;19(4):146-52. doi: 10.1016/j.tem.2007.12.001. Epub 2008 Mar 7.

Abstract

In recent decades, there has been a dramatic increase in the incidence of obesity in all age groups of the population in the USA. In addition to genetics and life style changes, the important role of metabolic programming effects in the etiology of the obesity epidemic is being increasingly recognized. Although the role of a compromised intrauterine environment in fetal metabolic programming is well documented to contribute to the development of adult-onset diseases, vulnerability in the immediate postnatal period to similar conditions has also been shown. Metabolic programming effects induced by altered nutritional experiences in the immediate postnatal period can give rise to long-term consequences in the context of the current obesity epidemic.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult
  • Animals
  • Animals, Newborn
  • Child Development / physiology*
  • Dietary Carbohydrates / pharmacology
  • Fetal Development / physiology
  • Humans
  • Infant Formula / chemistry
  • Infant Formula / pharmacology
  • Infant Nutritional Physiological Phenomena
  • Infant, Newborn / metabolism*
  • Metabolic Syndrome / etiology
  • Models, Animal
  • Models, Biological
  • Obesity / epidemiology
  • Obesity / etiology
  • Rats
  • Time Factors

Substances

  • Dietary Carbohydrates