CD83 regulates lymphocyte maturation, activation and homeostasis

Trends Immunol. 2008 Apr;29(4):186-94. doi: 10.1016/j.it.2008.01.009. Epub 2008 Mar 7.

Abstract

The transmembrane CD83 molecule, a conserved member of the immunoglobulin superfamily, is known as one of the most characteristic cell surface markers for fully matured dendritic cells (DCs) in the peripheral circulation. An essential role for CD83 on murine DCs has not been found; however, evidence shows that its function primarily lies in the regulation of T- and B-lymphocyte maturation and in the regulation of their peripheral responses. Here, we review evidence for a role of CD83 in central lymphocyte maturation and novel, sometimes contradictory findings, regarding the function of CD83 in peripheral immune responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / immunology*
  • Antigens, CD / metabolism*
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • Cell Differentiation
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Homeostasis
  • Humans
  • Immunoglobulins / immunology*
  • Immunoglobulins / metabolism*
  • Lymphocyte Activation*
  • Membrane Glycoproteins / immunology*
  • Membrane Glycoproteins / metabolism*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • Up-Regulation

Substances

  • Antigens, CD
  • CD83 antigen
  • Immunoglobulins
  • Membrane Glycoproteins