Efficacy of benzoxazinorifamycins in a mouse model of Chlamydia pneumoniae lung infection

Lee Ann Campbell; Cho-Chou Kuo; Robert J Suchland; David M Rothstein

doi:10.1128/AAC.01567-07

Efficacy of benzoxazinorifamycins in a mouse model of Chlamydia pneumoniae lung infection

Antimicrob Agents Chemother. 2008 May;52(5):1855-8. doi: 10.1128/AAC.01567-07. Epub 2008 Mar 10.

Authors

Lee Ann Campbell¹, Cho-Chou Kuo, Robert J Suchland, David M Rothstein

Affiliation

¹ Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA.

Abstract

The efficacy of rifalazil and other benzoxazinorifamycins was tested in a mouse model of lung infection against Chlamydia pneumoniae. Rifalazil and six related new chemical entities all showed efficacy after one dose per day for 3 days at either 3 or 1 mg/kg of body weight.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Chlamydia Infections / drug therapy*
Chlamydophila pneumoniae / drug effects*
Disease Models, Animal
Lung / drug effects*
Lung / microbiology
Male
Mice
Microbial Sensitivity Tests
Rifamycins / pharmacology*

Substances

Anti-Bacterial Agents
Rifamycins
KRM 1648