Hyperhidrosis treatment with bornaprine in the acute phase of spinal cord-injured patients

Spinal Cord. 2008 Aug;46(8):571-3. doi: 10.1038/sc.2008.12. Epub 2008 Mar 11.

Abstract

Study design: Original article.

Objective: To test the use of bornaprine in the hyperhidrosis treatment in the acute phase of spinal cord-injured patients.

Setting: Patients with acute spinal cord lesions in the Spinal Unit of Pietra Ligure, Savona, Italy.

Method: In 4 years, 12 patients have been treated, for a maximum period of 75 days, with dosages ranging from 2 to 4 mg day(-1).

Results: All of them reported long-lasting subjective benefits, without side effects, even after the interruption of the therapy.

Conclusion: The bornaprine treatment, at 2 or 4 mg day(-1) dosage, has been effective and safe to contrast hyperhidrosis, in the acute phase of spinal cord-injured patients. This positive experience would require additional trials and a larger number of cases to gain a more solid support.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bridged-Ring Compounds / therapeutic use*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hyperhidrosis / drug therapy*
  • Hyperhidrosis / etiology*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Spinal Cord Injuries / complications*
  • Spinal Cord Injuries / drug therapy

Substances

  • Bridged-Ring Compounds
  • bornaprine