S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease

J Alzheimers Dis. 2008 Feb;13(1):67-70. doi: 10.3233/jad-2008-13107.


Recent preclinical and clinical findings demonstrate that dietary supplementation with S-adenosyl methionine alleviates a variety of risk factors and hallmarks associated with Alzheimer's disease. These findings support and extend prior studies, some of which are decades old, and support the notion that nutritional supplementation may represent an important augmentation for therapy in Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • Aged
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / metabolism
  • Brain / metabolism
  • Cognition Disorders / epidemiology
  • Humans
  • Risk Factors
  • S-Adenosylmethionine / deficiency
  • S-Adenosylmethionine / therapeutic use*


  • S-Adenosylmethionine