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, 5 (3), e67

Observational Research, Randomised Trials, and Two Views of Medical Science

Affiliations

Observational Research, Randomised Trials, and Two Views of Medical Science

Jan P Vandenbroucke. PLoS Med.

Abstract

Two views exist of medical science, says the author, one emphasizing discovery and explanation, the other emphasizing evaluation of interventions.

Conflict of interest statement

Competing Interests: The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Axis of Haphazardness of Exposure
Figure 2
Figure 2. Axis of Multiplicity

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References

    1. Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, et al. Clinical trial registration—Looking back and moving ahead. N Engl J Med. 2007;356:2734–2736. - PubMed
    1. Vandenbroucke JP, Koster T, Briet E, Reitsma PH, Bertina RM, et al. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet. 1994;344:1453–1457. - PubMed
    1. Vandenbroucke JP, Rosendaal FR, Bertina RM. Factor V Leiden, oral contraceptives and deep vein thrombosis. In: Khoury JM, Little J, Burke W, editors. Human genome epidemiology. New York: Oxford University Press; 2004. pp. 322–332.
    1. Vandenbroucke JP, Rosing J, Bloemenkamp KW, Middeldorp S, Helmerhorst FM, et al. Oral contraceptives and the risk of venous thrombosis. N Engl J Med. 2001;344:1527–1535. - PubMed
    1. Vandenbroucke JP, Kroep JR. Bortezomib in multiple myeloma. N Engl J Med. 2005;353:1297–1298. - PubMed
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