Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene

Nature. 1991 Sep 26;353(6342):351-3. doi: 10.1038/353351a0.


The Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and bithorax (bx-C) complexes, and hence for the maintenance of segmental determination. We report the predicted protein sequence of the Pc-G gene Posterior Sex Combs (Psc), and of the neighbouring and related gene Suppressor two of zeste (Su(z)2). Both genes encode large proteins that contain a 200 amino-acid domain identical over 37.4% that is also conserved in the murine oncogene bmi-1. At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins*
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / chemistry*
  • Oncogene Proteins / chemistry*
  • Polycomb Repressive Complex 1
  • Proteins / chemistry*
  • Proteins / genetics
  • Proto-Oncogene Proteins*
  • Repressor Proteins*
  • Sequence Homology, Nucleic Acid
  • Zinc Fingers


  • Bmi1 protein, mouse
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Nuclear Proteins
  • Oncogene Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Su(z)2 protein, Drosophila
  • Psc protein, Drosophila
  • Polycomb Repressive Complex 1