GID1-mediated gibberellin signaling in plants

Trends Plant Sci. 2008 Apr;13(4):192-9. doi: 10.1016/j.tplants.2008.02.005. Epub 2008 Mar 11.


Gibberellin (GA) perception is mediated by GID1 (GA-INSENSITIVE DWARF1), a receptor that shows similarity to hormone-sensitive lipases. A key event in GA signaling is the degradation of DELLA proteins, which are negative regulators of GA response that interact with GID1 in a GA-dependent manner. This GID1-DELLA GA-perception system is conserved among vascular plants but is not found in the moss Physcomitrella patens. The identification of factors in GA signaling downstream of DELLA and the development of a new concept of DELLA function beyond its role as a repressor of GA signaling are important advances. DELLA proteins appear to have at least two other distinct roles: maintaining GA homeostasis and regulating cross-talk between GA and other plant hormones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arabidopsis Proteins / metabolism
  • Gibberellins / chemistry
  • Gibberellins / metabolism*
  • Gibberellins / pharmacology
  • Models, Biological
  • Molecular Structure
  • Plant Development
  • Plant Proteins / metabolism*
  • Plants / drug effects
  • Plants / metabolism
  • Protein Binding
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction*


  • Arabidopsis Proteins
  • GID1a protein, Arabidopsis
  • Gibberellins
  • Plant Proteins
  • Receptors, Cell Surface