Vitamin D regulation of cathelicidin in the skin: toward a renaissance of vitamin D in dermatology?

J Invest Dermatol. 2008 Apr;128(4):773-5. doi: 10.1038/jid.2008.35.

Abstract

1,25-Dihydroxyvitamin D(3), the active form of vitamin D, is a major regulator of the expression of the cationic antimicrobial peptide cathelicidin, not only in monocytes but also in epidermal keratinocytes. The involvement of cathelicidin in wound healing and skin diseases as diverse as psoriasis, rosacea, and atopic dermatitis may create new opportunities for the use of vitamin D in dermatology.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / genetics
  • Antimicrobial Cationic Peptides / metabolism*
  • Calcitriol / pharmacology
  • Calcitriol / physiology*
  • Calcitriol / therapeutic use*
  • Cathelicidins
  • Humans
  • Skin Diseases / drug therapy*
  • Skin Diseases / metabolism
  • Vitamin D / pharmacology
  • Vitamin D / physiology
  • Vitamin D / therapeutic use
  • Wound Healing / drug effects

Substances

  • Antimicrobial Cationic Peptides
  • Vitamin D
  • Calcitriol
  • Cathelicidins