Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer

Nat Rev Cancer. 2008 Apr;8(4):309-16. doi: 10.1038/nrc2346.


The importance of multidisciplinary translational clinical trials is obvious; however, making them work is complex and challenging. Here I present an argument for designing and implementing multidisciplinary mechanistic trials and present the lessons our team at the Massachusetts General Hospital Cancer Center has learned from two such trials in cancer patients with locally advanced rectal carcinomas and recurrent glioblastomas.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Animals
  • Clinical Trials as Topic
  • Humans
  • Neoplasms / blood supply*
  • Neovascularization, Pathologic / drug therapy*


  • Angiogenesis Inhibitors