[The Role of Alpha-Tocopherol and Thiamine in the Correction of Lipid Peroxidation in Compensatory Myocardial Hypertrophy]

Vopr Pitan. May-Jun 1991;(3):38-42.
[Article in Russian]

Abstract

Cardiac hypertrophy in rats was induced by the narrowing of the abdominal aorta 3.14 and 30 days before the experiment. It has been shown that activation of NADP.H production under these conditions leads to elevation of NADP.H-dependent lipid peroxidation (LPO) level and to decrease of glutathione reductase (GR) activity, that means that changes take place in the antioxidant state of the cardiac tissue. Use of alpha-tocopherol and thiamine normalizes LPO level and induces elevation of GR activity. These data when compared with those obtained in investigation of the cardiac pumping function during its intensive activity could be estimated as favourable prerequisites for prevention of cardiac insufficiency.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antioxidants
  • Cardiomegaly / drug therapy
  • Cardiomegaly / metabolism*
  • Disease Models, Animal*
  • Glutathione Reductase / antagonists & inhibitors
  • Glutathione Reductase / metabolism
  • Isocitrate Dehydrogenase / metabolism
  • Lipid Peroxidation / physiology*
  • Myocardium / metabolism*
  • NADP / metabolism
  • Rats
  • Thiamine / administration & dosage*
  • Vitamin E / administration & dosage*

Substances

  • Antioxidants
  • Vitamin E
  • NADP
  • Isocitrate Dehydrogenase
  • Glutathione Reductase
  • Thiamine