Autoimmune response to Chlamydia trachomatis infection and in vitro fertilization outcome

Arianna Pacchiarotti; Marco Sbracia; Mohamed A Mohamed; Antonio Frega; Alessandro Pacchiarotti; Salomè M B Espinola; Cesare Aragona

doi:10.1016/j.fertnstert.2007.12.009

Autoimmune response to Chlamydia trachomatis infection and in vitro fertilization outcome

Fertil Steril. 2009 Mar;91(3):946-8. doi: 10.1016/j.fertnstert.2007.12.009. Epub 2008 Mar 12.

Authors

Arianna Pacchiarotti¹, Marco Sbracia, Mohamed A Mohamed, Antonio Frega, Alessandro Pacchiarotti, Salomè M B Espinola, Cesare Aragona

Affiliation

¹ Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Policlinico Umberto Io, Università di Roma La Sapienza, Rome, Italy. arypac@aliceposta.it

PMID: 18339387
DOI: 10.1016/j.fertnstert.2007.12.009

Abstract

This observational study was conducted in 235 patients undergoing IVF who had a cervical swab positive for Chlamydia trachomatis and who underwent antibiotic treatment until a negative cervical swab before IVF attempt. After oocyte retrieval, follicular fluids of 109 patients out of 228 still showed the presence of IgA antichlamydia antibodies and a significantly lower pregnancy and implantation rate; therefore we conclude that patients should undergo IVF procedure after serum antichlamydia IgA tests negative.

Publication types

Multicenter Study

MeSH terms

Anti-Bacterial Agents / therapeutic use
Antibodies, Bacterial / metabolism
Autoimmunity*
Cervix Uteri / microbiology*
Chlamydia Infections / drug therapy
Chlamydia Infections / immunology
Chlamydia Infections / microbiology*
Chlamydia trachomatis / immunology
Chlamydia trachomatis / isolation & purification*
Embryo Implantation*
Female
Fertilization in Vitro*
Follicular Fluid / immunology
Follicular Fluid / microbiology
Humans
Immunoglobulin A / blood
Italy
Oocyte Retrieval
Pregnancy
Pregnancy Rate*
Time Factors

Substances

Anti-Bacterial Agents
Antibodies, Bacterial
Immunoglobulin A