Low oxygen stimulates the immune system

Kidney Int. 2008 Apr;73(7):797-9. doi: 10.1038/ki.2008.15.


Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basic Helix-Loop-Helix Transcription Factors / physiology
  • Cell Hypoxia / physiology*
  • Dendritic Cells / physiology
  • Hypoxia-Inducible Factor 1 / physiology
  • Immune System / physiology*
  • Kidney Diseases / etiology


  • Basic Helix-Loop-Helix Transcription Factors
  • Hypoxia-Inducible Factor 1
  • endothelial PAS domain-containing protein 1