Zinc in elderly people: effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: a Zincage study

Rejuvenation Res. 2008 Apr;11(2):479-83. doi: 10.1089/rej.2008.0680.


Zinc is relevant for psychological dimensions, which are altered in zinc deficiency, as in aging. Since zinc deficiency and the beneficial effect of zinc supplementation may be related to genotypes of IL-6 -174 polymorphism, the main goal was to examine psychological dimensions in relationship to plasma zinc and genetic background of IL-6 in healthy elderly subjects, recruited in Italy, Greece, and Poland, before and after zinc supplementation. On the basis of IL-6 -174 polymorphism, significant restoration occurs for PSS, especially in Greece and Poland, less for MMSE and GDS, after zinc supplementation, suggesting zinc is important in reducing stress in elderly people.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Affect / drug effects
  • Aged
  • Aged, 80 and over
  • Aging / drug effects*
  • Aging / psychology*
  • Cognition / drug effects
  • Dietary Supplements*
  • Genotype
  • Humans
  • Interleukin-6 / genetics*
  • International Cooperation*
  • Middle Aged
  • Polymorphism, Genetic / drug effects*
  • Stress, Psychological
  • Zinc / blood
  • Zinc / pharmacology*


  • Interleukin-6
  • Zinc