Multitasking of interferon regulatory factor-4 in early B cells

Peter Nielsen; Rudolf Grosschedl

doi:10.1016/j.immuni.2008.02.007

Multitasking of interferon regulatory factor-4 in early B cells

Immunity. 2008 Mar;28(3):295-7. doi: 10.1016/j.immuni.2008.02.007.

Authors

Peter Nielsen¹, Rudolf Grosschedl

Affiliation

¹ Max Planck Institute of Immunobiology, Freiburg, Germany.

PMID: 18342001
DOI: 10.1016/j.immuni.2008.02.007

Abstract

Immunoglobulin heavy- and light-chain genes are rearranged in a temporally ordered manner. In this issue, Johnson et al. (2008) show that interferon regulatory factor-4 regulates light-chain gene rearrangement by activating enhancers and attenuating interleukin-7 signaling.

Publication types

Comment
Review

MeSH terms

Animals
B-Lymphocytes / cytology*
B-Lymphocytes / immunology
Cell Differentiation / immunology*
Gene Rearrangement, B-Lymphocyte, Light Chain / immunology*
Humans
Interferon Regulatory Factors / immunology*
Interferon Regulatory Factors / metabolism
Interleukin-7 / immunology
Interleukin-7 / metabolism
Signal Transduction / immunology
Stem Cells / cytology*
Stem Cells / immunology

Substances

Interferon Regulatory Factors
Interleukin-7
interferon regulatory factor-4