Apocrine carcinomas of the breast in Turkish women: hormone receptors, c-erbB-2 and p53 immunoexpression

Pathol Res Pract. 2008;204(6):367-71. doi: 10.1016/j.prp.2008.01.012. Epub 2008 Mar 14.


The aims of this study were twofold: (i) to determine the occurrence frequency of apocrine carcinoma of the breast (ApBCa) in Turkish breast cancer (BCa) patients; and (ii) to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), gross cystic disease protein-15 (GCDFP-15), c-erbB-2, and p53 in these cases. Six hundred and twenty-six cases of BCa were studied immunohistochemically (streptoavidin-biotin horseradish peroxidase method). The results of ApBCa were compared with those of invasive ductal carcinoma not otherwise specified type (IDC-NOS) cases of similar grade. Thirteen cases of ApBCa were encountered, accounting for 2.1% of all BCa cases. Immunohistochemically, ApBCa positivity was as follows: GCDFP-15 (100%), ER (39%), PR (8%), AR (54%), p53 (39%), and c-erbB-2 (85%). In the IDC-NOS group, GCDFP-15* was expressed in less than 50% of the tumors. The occurrence frequencies of the other markers were as follows: ER (69%), PR (69%)*, AR (46%), c-erbB-2 (0%)*, and p53 (31%), (*) indicating significant differences between the two groups. For Turkish BCa patients, (i) the occurrence rate of ApBCa (2.1%) was high; and (ii) the following combination would allow for an immunohistochemical identification of ApBCa: GCDFP-15(+), c-erbB-2(+), and PR(-).

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Apocrine Glands / metabolism
  • Apocrine Glands / pathology
  • Biomarkers, Tumor / metabolism
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / metabolism
  • Carcinoma, Ductal, Breast / pathology
  • Carrier Proteins / metabolism
  • Female
  • Glycoproteins / metabolism
  • Humans
  • Immunoenzyme Techniques
  • Membrane Transport Proteins
  • Middle Aged
  • Receptor, ErbB-2 / metabolism*
  • Receptors, Steroid / metabolism*
  • Sweat Gland Neoplasms / metabolism*
  • Sweat Gland Neoplasms / pathology
  • Tumor Suppressor Protein p53 / metabolism*


  • Biomarkers, Tumor
  • Carrier Proteins
  • Glycoproteins
  • Membrane Transport Proteins
  • PIP protein, human
  • Receptors, Steroid
  • Tumor Suppressor Protein p53
  • Receptor, ErbB-2