MRI contrast media are used to improve visualization of abnormal structures or lesions in various parts of the body. Introduction

Eur J Radiol. 2008 May;66(2):153-9. doi: 10.1016/j.ejrad.2008.01.022. Epub 2008 Mar 14.


Until recently it was believed that extracellular gadolinium based contrast agents (Gd-CA) were safe for both the kidneys and all other organs within the dose range up to 0.3mmol/kg body weight. However, in 2006, it was demonstrated that some Gd-CA may trig the development of nephrogenic systemic fibrosis, a generalized fibrotic disorder, in renal failure patients. This sub-section of European Journal of Radiology covers the current knowledge about NSF from many aspects. The prevention of NSF must be given high priority, but it should not lead to a denial of a well-justified, enhanced MRI examination with a stable agent.

Publication types

  • Introductory Journal Article

MeSH terms

  • Contrast Media / adverse effects*
  • Contrast Media / chemistry
  • Fibrosis / chemically induced
  • Gadolinium / adverse effects*
  • Gadolinium / chemistry
  • Humans
  • Image Enhancement / methods*
  • Kidney Diseases / chemically induced*
  • Magnetic Resonance Imaging*
  • Skin Diseases / chemically induced*


  • Contrast Media
  • Gadolinium