Multicellular dynamics during epithelial elongation

Semin Cell Dev Biol. 2008 Jun;19(3):263-70. doi: 10.1016/j.semcdb.2008.01.005. Epub 2008 Feb 2.


The reorganization of multicellular populations to produce an elongated tissue structure is a conserved mechanism for shaping the body axis and several organ systems. In the Drosophila germband epithelium, this process is accompanied by the formation of a planar polarized network of junctional and cytoskeletal proteins in response to striped patterns of gene expression. Actomyosin cables and adherens junctions are dynamically remodeled during intercalation, providing the basis for polarized cell behavior. Quantitative analysis of cell behavior in living embryos reveals unexpected cell population dynamics that include the formation of multicellular rosette structures as well as local neighbor exchange.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cell Differentiation*
  • Cell Polarity
  • Cytoskeleton / metabolism
  • Drosophila melanogaster / cytology
  • Epithelial Cells / cytology*