Analysis of selective production of Nalpha-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde and Nalpha-benzyloxycarbonyl-L-aminoadipic acid by Rhodococcus sp. AIU Z-35-1

J Biosci Bioeng. 2008 Feb;105(2):152-6. doi: 10.1263/jbb.105.152.

Abstract

The factors for selective production of N(alpha)-benzyloxycarbonyl-L-aminoadipate-delta-semialdehyde (N(alpha)-Z-L-AASA) and N(alpha)-benzyloxycarbonyl-L-aminoadipic acid (N(alpha)-Z-L-AAA) from N(alpha)-benzyloxycarbonyl-L-lysine (N(alpha)-Z-L-lysine) by Rhodococcus sp. AIU Z-35-1 were analyzed. The cultivation time was important for selective production of N(alpha)-Z-L-AASA, since N(alpha)-Z-L-lysine oxidizing enzyme reached maximum at the early stage of cell growth and then decreased. The differences of enzyme activities of N(alpha)-Z-L-lysine oxidizing enzyme and N(alpha)-Z-L-AASA dehydrogenase in pH and temperature also affected the selective production of N(alpha)-Z-L-AASA. For efficient production of N(alpha)-Z-L-AAA, it was important for cultivation time that N(alpha)-Z-L-AASA dehydrogenase activity be higher than N(alpha)-Z-L-lysine oxidizing enzyme activity, since a high concentration of N(alpha)-Z-L-AASA inhibited N(alpha)-Z-L-AASA dehydrogenase activity. The optimum pH of N(alpha)-Z-L-AAA production was affected by the instability of N(alpha)-Z-L-AASA dehydrogenase in the alkaline pH region.

MeSH terms

  • 2-Aminoadipic Acid / analogs & derivatives*
  • 2-Aminoadipic Acid / metabolism
  • Bacterial Proteins / metabolism*
  • Bioreactors / microbiology*
  • Cell Culture Techniques / methods*
  • Oxidoreductases Acting on CH-NH Group Donors / metabolism*
  • Rhodococcus / classification*
  • Rhodococcus / metabolism*
  • Species Specificity

Substances

  • Bacterial Proteins
  • N(alpha)-benzyloxycarbonyl-aminoadipic acid
  • N(alpha)-benzyloxycarbonylaminoadipic acid delta-semialdehyde
  • 2-Aminoadipic Acid
  • Oxidoreductases Acting on CH-NH Group Donors
  • delta-1-piperideine-6-carboxylate dehydrogenase