Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes

Eur J Heart Fail. 2008 Apr;10(4):380-7. doi: 10.1016/j.ejheart.2008.02.012. Epub 2008 Mar 17.


Background: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown.

Aims: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF.

Methods and results: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n=48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P=0.012), but not in CHF patients without DM (P=0.45); vWf levels were also higher in CHF patients with DM (P<0.001), but not without DM (P=0.108). E-selectin was associated with risk of recurrent ischaemic cardiovascular events among CHF patients with DM (HR 2.60; P=0.009), but not among patients without DM (HR 1.09; P=0.60) per 1 SD increment in log transformed variable. vWf was not related with outcome in CHF patients with or without DM.

Conclusions: Plasma levels of E-selectin and vWf are elevated in CHF patients with DM but not in those without DM. High E-selectin levels may be associated with ischaemic events in patients with DM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Diabetes Mellitus / blood*
  • E-Selectin / blood*
  • Endothelium, Vascular / physiopathology*
  • Female
  • Heart Failure / blood*
  • Heart Failure / diagnosis
  • Heart Failure / mortality
  • Humans
  • Male
  • Middle Aged
  • Myocardial Ischemia / blood
  • Myocardial Ischemia / diagnosis
  • Myocardial Ischemia / mortality
  • Prognosis
  • Proportional Hazards Models
  • Risk Factors
  • Survival Analysis
  • von Willebrand Factor / metabolism*


  • Biomarkers
  • E-Selectin
  • von Willebrand Factor