Acneiform eruption due to "megadose" vitamins B6 and B12

Cutis. 1991 Aug;48(2):119-20.


Medications and other exogenous factors are known to be capable of exacerbating acne or precipitating acneiform eruptions. This case illustrates an eruption resembling acne rosacea that was temporally associated with daily ingestion of high-dose B vitamin supplement. The eruption failed to respond to the usual treatment regimens for rosacea, but promptly improved when use of the vitamin supplement was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Acne Vulgaris / chemically induced*
  • Drug Eruptions / etiology*
  • Female
  • Humans
  • Middle Aged
  • Pyridoxine / administration & dosage
  • Pyridoxine / adverse effects*
  • Vitamin B 12 / administration & dosage
  • Vitamin B 12 / adverse effects*


  • Pyridoxine
  • Vitamin B 12