Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate

J Pharmacol Sci. 2008 Mar;106(3):525-8. doi: 10.1254/jphs.sc0070291. Epub 2008 Mar 12.


In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [(3)H]PGE(2) transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Dinoprostone / metabolism
  • Fatty Acids, Volatile / metabolism*
  • Mice
  • Organic Anion Transporters, Sodium-Independent / physiology*
  • Propionates / metabolism*
  • Xenopus


  • Fatty Acids, Volatile
  • Organic Anion Transporters, Sodium-Independent
  • Propionates
  • Slc22a7 protein, mouse
  • Dinoprostone