A quantitative analysis software tool for mass spectrometry-based proteomics

Nat Methods. 2008 Apr;5(4):319-22. doi: 10.1038/nmeth.1195. Epub 2008 Mar 16.


We describe Census, a quantitative software tool compatible with many labeling strategies as well as with label-free analyses, single-stage mass spectrometry (MS1) and tandem mass spectrometry (MS/MS) scans, and high- and low-resolution mass spectrometry data. Census uses robust algorithms to address poor-quality measurements and improve quantitative efficiency, and it can support several input file formats. We tested Census with stable-isotope labeling analyses as well as label-free analyses.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Mass Spectrometry / methods*
  • Peptides / analysis*
  • Proteomics / methods*
  • Software*
  • Tandem Mass Spectrometry / methods


  • Peptides