The urokinase receptor and integrins in cancer progression

Cell Mol Life Sci. 2008 Jun;65(12):1916-32. doi: 10.1007/s00018-008-7573-9.

Abstract

Enhanced levels of expression of urokinase receptor (uPAR) and certain integrins have been linked to cancer cell progression. This has classically been attributed to matrix degradation via the activation of the urokinase (uPA)/plasmin system and modulation of cell motility and survival through integrin engagement. More recently, uPAR has been shown to play multiple roles independent of protease activity. Specifically, uPAR has been shown to be intimately involved in the regulation of cell adhesion, migration and proliferation in part through interactions with other membrane partners, including integrins. The goal of this review is to summarize recent insights in the function of uPAR/integrin interactions, to provide a framework for understanding the importance of these interactions in the context of cancer, and to highlight its potential as a target for therapeutic intervention.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Disease Progression
  • Integrin alpha Chains / metabolism
  • Integrin beta Chains / metabolism
  • Integrins / chemistry
  • Integrins / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism*
  • Receptors, Urokinase Plasminogen Activator
  • Signal Transduction

Substances

  • Integrin alpha Chains
  • Integrin beta Chains
  • Integrins
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator