Platelet-derived growth factor is mitogenic for O-2Aadult progenitor cells

Glia. 1991;4(5):495-503. doi: 10.1002/glia.440040509.


We report that platelet-derived growth factor (PDGF) is a potent mitogen for oligodendrocyte type-2 astrocyte (O-2A) progenitor cells derived from the optic nerves of adult rats. Moreover, O-2Aadult progenitors cultured in PDGF express the range of properties we have described previously for O-2Aadult progenitors cultured in the presence of type-1 astrocytes. Similarly, previous studies have demonstrated that PDGF is able to mimic the influence of type-1 astrocytes on O-2Aperinatal progenitors. Specifically, O-2Aadult progenitors and O-2Aperinatal progenitors exposed to PDGF express differences in average cell cycle time (59 +/- 5 h for O-2Aadult progenitors versus 20 +/- 6 h for O-2Aperinatal progenitors), average rate of migration (4.1 +/- 0.6 microns h-1 versus 24.6 +/- 5.4 microns h-1), morphology (unipolar versus bipolar), and antigenic phenotype (04+ vimentin- versus 04- vimentin+). Thus, our present results indicate that a single signalling molecule secreted by type-1 astrocytes produces markedly different cellular behaviours in two related O-2A progenitor populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / immunology
  • Antibodies, Monoclonal / immunology
  • Antigens / immunology
  • Cell Division
  • Cell Movement
  • Culture Media
  • Mitogens / pharmacology*
  • Oligodendroglia / cytology
  • Oligodendroglia / drug effects*
  • Phenotype
  • Platelet-Derived Growth Factor / immunology
  • Platelet-Derived Growth Factor / pharmacology*
  • Stem Cells / cytology
  • Stem Cells / drug effects*
  • Time Factors
  • Vimentin / immunology


  • Antibodies
  • Antibodies, Monoclonal
  • Antigens
  • Culture Media
  • Mitogens
  • Platelet-Derived Growth Factor
  • Vimentin