Molecular cloning and characterization of the rat NMDA receptor

Nature. 1991 Nov 7;354(6348):31-7. doi: 10.1038/354031a0.


A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism*
  • Cloning, Molecular
  • Electrophysiology
  • Ibotenic Acid / analogs & derivatives
  • Ibotenic Acid / chemistry
  • Kainic Acid / chemistry
  • Molecular Sequence Data
  • Molecular Structure
  • RNA, Messenger / analysis
  • Rats
  • Receptors, N-Methyl-D-Aspartate / genetics*
  • Xenopus / genetics
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid


  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate
  • Ibotenic Acid
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
  • Kainic Acid