Diagnosis of cytomegalovirus pneumonia in compromised hosts

Am J Med. 1976 Sep;61(3):326-32. doi: 10.1016/0002-9343(76)90368-5.


Sixteen patients with cytomegalovirus pulmonary infection are described. In 11 the diagnosis was made antemortem by lung aspirate or biopsy, and in five the diagnosis was made at postmortem by typical lung histology and positive viral lung cultures. All patients were immunosuppressed by both their underlying diseases and treatment with corticosteroids and other chemotherapy. Although other pathogens were identified at lung biopsy in most patients (73 per cent), primarily Pneumocystis carinii, evidence is offered to demonstrate that cytomegalovirus can cause significant pulmonary disease alone, leading to respiratory failure and death.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / diagnosis*
  • Cytomegalovirus Infections / pathology
  • Female
  • Humans
  • Lung / pathology
  • Lung Diseases / complications
  • Male
  • Middle Aged
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / diagnosis*