Headache in primary Sjögren's syndrome: a prevalence study

Acta Neurol Scand. 2008 Sep;118(3):189-92. doi: 10.1111/j.1600-0404.2008.00997.x. Epub 2008 Mar 18.


Objectives: To determine the prevalence of headache in patients with primary Sjögren's syndrome (pSS) and to examine the relationship between headache types and clinical, serologic features of the disease.

Methods: The study enclosed 133 patients with the diagnoses of pSS and 97 healthy controls. A questionnaire designed to assess the presence of headache and if present to classify it according to the criteria of the International Headache Society was used.

Results: In 133 of the pSS patients evaluated, 104 had headache. No association was present between types of headache and the clinical and laboratory manifestations of the disease. Both migraine and tension-type headache were more common in patients with pSS when compared with healthy controls (P < 0.001).

Conclusions: The high prevalence of migraine in pSS patients might be explained by a vascular headache triggered by immuno-mediated disease activity without an obvious clinic or laboratory marker.

MeSH terms

  • Cross-Sectional Studies
  • Female
  • Headache / epidemiology*
  • Headache / etiology*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Sjogren's Syndrome / complications*
  • Surveys and Questionnaires