Idiopathic tracheal stenosis: successful outcome with antigastroesophageal reflux disease therapy

Ann Thorac Surg. 2008 Apr;85(4):1438-9. doi: 10.1016/j.athoracsur.2007.10.032.


There is controversial evidence that gastroesophageal reflux disease (GERD) is an etiologic factor for idiopathic laryngotracheal stenosis. We present the case of a 44-year-old woman with symptomatic tracheal stenosis managed as idiopathic stenosis. She underwent six endoscopic dilations during 1 year, and before surgery she underwent 24-hour esophageal pH monitoring that documented GERD. Anti-GERD treatment was started, which was confirmed as effective with 24-hour esophageal pH monitoring 3 months later. At 2-year follow-up the patient remained free of symptoms and no additional airway procedure was necessary. A close relationship between anti-GERD therapy and clinical outcome was noted.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Biopsy, Needle
  • Bronchoscopy / methods
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Dyspnea / diagnosis
  • Dyspnea / etiology
  • Enzyme Inhibitors / administration & dosage*
  • Esophageal pH Monitoring
  • Esophagoscopy
  • Female
  • Follow-Up Studies
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / drug therapy
  • Humans
  • Immunohistochemistry
  • Omeprazole / administration & dosage*
  • Severity of Illness Index
  • Tracheal Stenosis / drug therapy*
  • Tracheal Stenosis / etiology*
  • Tracheal Stenosis / pathology
  • Treatment Outcome


  • Enzyme Inhibitors
  • Omeprazole