Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 18 (1), 48-53

Recent Advances in Cancer Stem Cells


Recent Advances in Cancer Stem Cells

Robert W Cho et al. Curr Opin Genet Dev.


The theory of cancer stem cells states that a subset of cancer cells within a tumor has the ability to self-renew and differentiate. Only those cells within a tumor that have these two properties are called cancer stem cells. This concept was first demonstrated in the study of leukemia where only cells with specific surface antigen profiles were able to cause leukemia when engrafted into immunodeficient mice. In recent years solid tumors were studied utilizing similar techniques in mice. Human tumors where evidence of cancer stem cells has been published include tumors of the breast, brain, pancreas, head and neck, and colon. If this difference in tumorigenicity of cancer cells also occurs in patients, then the ability to enrich for cancer stem cells lays an important groundwork for future studies where mechanisms involved in cancer stem cells can now be investigated.

Similar articles

  • [Cancer Stem Cells in Solid Tumors]
    H Hirose et al. Gan To Kagaku Ryoho 37 (13), 2809-12. PMID 21160254. - Review
    In this review, we discuss recent issues about cancer stem cells, especially in solid tumors. Cancer stem cells show the ability to self-renew; and they possess multi-pot …
  • Signaling Pathways in Self-Renewing Hematopoietic and Leukemic Stem Cells: Do All Stem Cells Need a Niche?
    A Rizo et al. Hum Mol Genet 15 Spec No 2, R210-9. PMID 16987886. - Review
    Many adult tissue stem cells, such as the cells of the hematopoietic system, gastrointestinal epithelium, brain, epidermis, mammary gland and lung have now been identifie …
  • Cancer Stem Cells in Solid Tumors
    O Er. Onkologie 32 (10), 605-9. PMID 19816080.
    Carcinogenesis and tumor cell biology are very complex subjects. Recent findings on cancer stem cells may have a great impact on the understanding of the biology of malig …
  • Self-renewal and Solid Tumor Stem Cells
    M Al-Hajj et al. Oncogene 23 (43), 7274-82. PMID 15378087. - Review
    Solid tumors arise in organs that contain stem cell populations. The tumors in these tissues consist of heterogeneous populations of cancer cells that differ markedly in …
  • Cancer Stem Cells and Their Niche
    H Iwasaki et al. Cancer Sci 100 (7), 1166-72. PMID 19432904. - Review
    The unique characteristics of stem cells, specifically pluripotency and self-renewal, are critical for sustaining the lifelong functionality of organs. Stem cells reside …
See all similar articles

Cited by 87 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources