Complex sesquiterpenoids with tyrosinase inhibitory activity from the leaves of Chloranthus tianmushanensis

Bin Wu; Jun Chen; Haibin Qu; Yiyu Cheng

doi:10.1021/np070623r

Complex sesquiterpenoids with tyrosinase inhibitory activity from the leaves of Chloranthus tianmushanensis

J Nat Prod. 2008 May;71(5):877-80. doi: 10.1021/np070623r. Epub 2008 Mar 22.

Authors

Bin Wu¹, Jun Chen, Haibin Qu, Yiyu Cheng

Affiliation

¹ Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, PR China.

PMID: 18357995
DOI: 10.1021/np070623r

Abstract

Investigation of the leaves of Chloranthus tianmushanensis resulted in the isolation and characterization of two new sesquiterpene dimers with a rare 18-membered triester ring, tianmushanol (1) and 8-O-methyltianmushanol (2), and four known sesquiterpenes. Their structures were established by spectroscopic means. The inhibitory activities against tyrosinase of all isolates were also evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology*
Molecular Structure
Monophenol Monooxygenase / antagonists & inhibitors*
Plant Leaves / chemistry
Plants, Medicinal / chemistry*
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology*

Substances

8-O-methyltianmushanol
Drugs, Chinese Herbal
Sesquiterpenes
tianmushanol
Monophenol Monooxygenase