Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma

Eur J Cancer. 1991;27(11):1356-61. doi: 10.1016/0277-5379(91)90009-3.


Positron emission tomography (PET) has been used to measure changes in regional blood-brain barrier (BBB) permeability in patients with primary cerebral lymphoma undergoing radiotherapy and chemotherapy. The method employed is to measure the rate of wash-out of a radioactive tracer (68Ga-EDTA) from blood into brain tissue using time-sequence PET imaging. Preliminary studies carried out on patients with more common primary cerebral tumours show that time-activity data are reproducible to approximately 10%. Measurements made in 2 patients with primary cerebral lymphoma treated with initial chemotherapy showed significant changes in permeability in the region of the tumour. Within 5 weeks of the start of treatment, permeability values reached the levels of normal brain. No changes in BBB permeability in normal brain were seen immediately after radiotherapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood-Brain Barrier / physiology*
  • Brain / diagnostic imaging
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / radiotherapy
  • Cerebral Cortex
  • Edetic Acid
  • Female
  • Gallium Radioisotopes
  • Humans
  • Lymphoma / drug therapy
  • Lymphoma / metabolism*
  • Lymphoma / radiotherapy
  • Male
  • Middle Aged
  • Time Factors
  • Tomography, Emission-Computed


  • Gallium Radioisotopes
  • Edetic Acid