Linking cohesin to gene regulation

Cell. 2008 Mar 21;132(6):925-8. doi: 10.1016/j.cell.2008.03.001.

Abstract

During cell division the cohesin complex mediates the pairing of sister chromatids. Emerging evidence shows that cohesin also has roles in interphase cells. New studies, including that of Gullerova and Proudfoot (2008) in this issue, reveal how cohesin is targeted to specific sites on chromosomes and implicate cohesin in the regulation of gene expression.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Cycle Proteins / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Chromosomes / metabolism
  • Evolution, Molecular
  • Gene Expression Regulation*
  • Nuclear Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Nuclear Proteins
  • cohesins