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, 582 (9), 1325-9

Sendai Virus F Glycoprotein Induces IL-6 Production in Dendritic Cells in a Fusion-Independent Manner

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Sendai Virus F Glycoprotein Induces IL-6 Production in Dendritic Cells in a Fusion-Independent Manner

Hayato Suzuki et al. FEBS Lett.

Abstract

We previously reported that inactivated Sendai virus particle (hemagglutinating virus of Japan envelope; HVJ-E) has anti-tumor effects by eliciting IL-6 production in dendritic cells (DCs). In the present study, we investigated which components of HVJ-E elicit IL-6 production. HVJ-E containing F0 protein inactive for virus envelope-cell membrane fusion enhanced IL-6 production. Reconstituted liposomes containing F protein stimulated IL-6 production. The antibody against F protein inhibited IL-6 secretion by HVJ-E. When carbohydrate chains of the F glycoprotein were removed, HVJ-E lost the ability to stimulate IL-6 secretion. These results suggest that F glycoprotein is required for IL-6 production in DCs.

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