Objective: To analyze the role of luteal E(2), P, and FSH levels in the prediction of clinical pregnancy in stimulated cycles.
Design: Prospective study.
Setting: Institute of Reproductive Medicine, Salt Lake, Kolkata, India.
Patient(s): A total of 268 women aged <40 years undergoing their first IVF-ET/intracytoplasmic sperm injection cycles.
Intervention(s): Estimation of luteal phase serum E(2), P, and FSH levels on days 0, 7, and 14 of ET.
Main outcome measure(s): Comparison of luteal phase hormonal profile in pregnant and nonpregnant women and interpretation by discriminant analysis.
Result(s): A total of 113 pregnancies were achieved (42.16%). Age, basal FSH level, peak E(2) level, number of oocytes retrieved, and number of embryos transferred were comparable between pregnant and nonpregnant women. Day-7 and day-14 luteal E(2) levels were significantly different between the two groups. Progesterone levels were comparable in both groups on days 0 and 14. Levels of FSH showed statistically significant differences between the two groups on days 0, 7, and 14. Classification accuracy for E(2), P, and FSH was 82.1%, 60.8%, and 67.51%, respectively.
Conclusion(s): Luteal E(2) concentration seems to be a promising marker of successful clinical pregnancy.