A note on twin-singleton differences in asthma

Twin Res Hum Genet. 2008 Apr;11(2):161-4. doi: 10.1375/twin.11.2.161.


Twins constitute a valuable resource for genetic studies of asthma. However, critics argue that twins are 'special' in terms of prenatal environment and upbringing and therefore nonrepresentative. In respect to asthma a small range of studies report differential morbidity in twins compared with singletons. We review some of the possible explanations for these findings and conclude that results from twin studies of asthma can be extrapolated to the general population.

Publication types

  • Review

MeSH terms

  • Asthma / epidemiology
  • Asthma / genetics*
  • Diseases in Twins / epidemiology
  • Diseases in Twins / genetics*
  • Humans
  • Incidence
  • Prevalence
  • Research Design
  • Twin Studies as Topic