Abstract
Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / metabolism*
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Antimalarials / pharmacology*
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Atovaquone / metabolism
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Atovaquone / pharmacology
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Benzamidines / metabolism*
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Benzamidines / pharmacology*
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Chloroquine / metabolism
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Chloroquine / pharmacology
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Drug Interactions
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
Substances
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Antimalarials
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Benzamidines
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furamidine
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Chloroquine
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pafuramidine
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Atovaquone