Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro

Antimicrob Agents Chemother. 2008 Jun;52(6):2253-5. doi: 10.1128/AAC.01536-07. Epub 2008 Mar 24.

Abstract

Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / metabolism*
  • Antimalarials / pharmacology*
  • Atovaquone / metabolism
  • Atovaquone / pharmacology
  • Benzamidines / metabolism*
  • Benzamidines / pharmacology*
  • Chloroquine / metabolism
  • Chloroquine / pharmacology
  • Drug Interactions
  • Parasitic Sensitivity Tests
  • Plasmodium falciparum / drug effects*

Substances

  • Antimalarials
  • Benzamidines
  • furamidine
  • Chloroquine
  • pafuramidine
  • Atovaquone