Treatment of health complaints attributed to amalgam

J Dent Res. 2008 Apr;87(4):349-53. doi: 10.1177/154405910808700410.


The aim of the present study was to compare the reduction of subjective complaints by 3 treatment strategies in 90 "amalgam patients" whose complaints could not be explained by a medical or psychological disorder. The individuals were randomly assigned either to removal of dental amalgam only (removal group), or removal in combination with a "biological detoxification" therapy with high doses of vitamins and trace elements (removal-plus group), or participation in a health promotion program without removal of dental amalgam (no-removal group). Between baseline and month 12, the sum score of main complaints decreased by 3.5 (SD=2.2) points on average in the removal group as well as in the removal-plus group, and by 2.5 (SD=2.4) points in the no-removal group (p=0.152). Both removal groups showed a significant decrease in steady-state levels of inorganic mercury compared with the no-removal group. Thus, all 3 interventions were associated with clinically relevant improvements.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Clinical Protocols
  • Composite Resins
  • Dental Amalgam / adverse effects*
  • Dental Porcelain
  • Dental Restoration, Permanent / adverse effects*
  • Erythrocytes / pathology
  • Follow-Up Studies
  • Gold Alloys
  • Health Behavior
  • Health Promotion
  • Humans
  • Life Style
  • Mercury / blood
  • Mercury / urine
  • Middle Aged
  • Somatoform Disorders / therapy*
  • Trace Elements / therapeutic use
  • Treatment Outcome
  • Vitamins / therapeutic use


  • Composite Resins
  • Gold Alloys
  • Trace Elements
  • Vitamins
  • Dental Porcelain
  • Dental Amalgam
  • Mercury

Associated data

  • ISRCTN/ISRCTN51459238