Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort

Ophthalmic Genet. 2008 Mar;29(1):11-5. doi: 10.1080/13816810701663527.

Abstract

Background: Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR.

Materials and methods: Type 2 diabetic patients with and without retinopathy were recruited. The -634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests.

Results: No significant association was observed between genotypes, alleles and haplotypes of -634C/G and 936C/T polymorphisms and DR or its severity. However, C(-634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3).

Conclusion: Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Albuminuria / etiology
  • Asians / genetics*
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / genetics
  • Diabetes Mellitus, Type 2 / urine
  • Diabetic Retinopathy / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • India
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Vascular Endothelial Growth Factor A / genetics*

Substances

  • Vascular Endothelial Growth Factor A