Synaptic endocytosis: illuminating the role of clathrin assembly

Curr Biol. 2008 Mar 25;18(6):R259-61. doi: 10.1016/j.cub.2008.02.014.


Acute photo-inactivation of clathrin in Drosophila synapses sheds new light on a 35-year-old debate over mechanisms of synaptic-vesicle endocytosis: clathrin is essential for reformation of functional synaptic vesicles, but not for bulk membrane internalization.

MeSH terms

  • Animals
  • Clathrin / metabolism*
  • Drosophila
  • Dynamins / metabolism
  • Endocytosis / physiology*
  • Synaptic Vesicles / metabolism*


  • Clathrin
  • Dynamins