Efficient DNA pairing in a Neurospora mutant defective in chromosome pairing

Mol Gen Genet. 1991 Dec;231(1):49-52. doi: 10.1007/BF00293820.


A Neurospora crassa mutation, mei-2, affecting recombination and pairing of homologous chromosomes during meiosis, was characterized for its effect on repeat-induced point mutation (RIP). We found that RIP, which depends on recognition of DNA sequence homology, is not inhibited by mei-2, suggesting that the defect in chromosome pairing of this mutant is not due to a defect in DNA pairing and that DNA pairing is not dependent on chromosome pairing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Ampicillin / pharmacology
  • Chromosomes, Fungal / metabolism*
  • Crosses, Genetic
  • DNA, Fungal / metabolism*
  • Drug Resistance, Microbial / genetics
  • Genes, Fungal / genetics
  • Mutation / genetics
  • Neurospora crassa / drug effects
  • Neurospora crassa / genetics*
  • Recombination, Genetic / genetics*


  • DNA, Fungal
  • Ampicillin