Tau kinases and phosphatases

doi:10.1111/j.1582-4934.2007.00214.x

Comment

. 2008 Jan-Feb;12(1):258-9.

doi: 10.1111/j.1582-4934.2007.00214.x.

Tau kinases and phosphatases

J Avila¹

Affiliations

PMID: 18366453
PMCID: PMC3823486
DOI: 10.1111/j.1582-4934.2007.00214.x

Comment

Tau kinases and phosphatases

J Avila. J Cell Mol Med. 2008 Jan-Feb.

. 2008 Jan-Feb;12(1):258-9.

doi: 10.1111/j.1582-4934.2007.00214.x.

Author

J Avila¹

Affiliation

¹ Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1 Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain. javila@cbm.uam.es

PMID: 18366453
PMCID: PMC3823486
DOI: 10.1111/j.1582-4934.2007.00214.x

No abstract available

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Figures

1
Insulin (or related compounds) signalling could affect, in two opposite ways, to tau phosphorylation. In one way (left), it will inhibit the main tau kinase (GSK3), decreasing the modification in tau molecule. On the other hand (right), it will decrease PP2A activity, increasing the level of tau phosphorylation. It seems that the overall effect, from these opposite effects, is an increase in tau phosphorylation.

See this image and copyright information in PMC

Comment on

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA, Winblad B, Pei JJ. Liu R, et al. J Cell Mol Med. 2008 Jan-Feb;12(1):241-57. doi: 10.1111/j.1582-4934.2008.00249.x. Epub 2008 Jan 19. J Cell Mol Med. 2008. PMID: 18208556 Free PMC article.

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References

1. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA. 1985;82:4245–9. - PMC - PubMed
1. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem. 1986;261:6084–9. - PubMed
1. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986;83:4913–7. - PMC - PubMed
1. Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA. 1997;94:298–303. - PMC - PubMed
1. Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB. Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell. 2007;18:5060–8. - PMC - PubMed

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[1] Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA. 1985;82:4245–9. - PMC - PubMed

[2] Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA. 1985;82:4245–9. - PMC - PubMed

[3] Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem. 1986;261:6084–9. - PubMed

[4] Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem. 1986;261:6084–9. - PubMed

[5] Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986;83:4913–7. - PMC - PubMed

[6] Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986;83:4913–7. - PMC - PubMed

[7] Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA. 1997;94:298–303. - PMC - PubMed

[8] Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA. 1997;94:298–303. - PMC - PubMed

[9] Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB. Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell. 2007;18:5060–8. - PMC - PubMed

[10] Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB. Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell. 2007;18:5060–8. - PMC - PubMed

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Tau kinases and phosphatases

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