The Severe Respiratory Insufficiency Questionnaire was valid for COPD patients with severe chronic respiratory failure

J Clin Epidemiol. 2008 Aug;61(8):848-53. doi: 10.1016/j.jclinepi.2007.09.009. Epub 2008 Mar 25.


Objectives: The Severe Respiratory Insufficiency (SRI) Questionnaire has recently been developed and validated for the assessment of health-related quality of life (HRQL) in patients with severe chronic respiratory failure resulting from a broad spectrum of underlying disorders. The present study was aimed at reexamining the internal structure of the SRI specifically for chronic obstructive pulmonary disease (COPD) patients.

Study design and setting: Cross-validation was performed in two COPD groups (N=78 and N=84), each receiving home mechanical ventilation in addition to long-term oxygen therapy. The internal consistency reliability was calculated using Cronbach's alpha coefficient. Explorative Factor Analysis was performed followed by Confirmatory Factor Analysis to establish construct validity.

Results: In the total group (N=162) Cronbach's alpha ranged from 0.73 to 0.88. Only one factor could be established which explained 58.5% of the total variance confirming one Summary Scale (SRI-SS). For each of the seven subscales, Confirmatory Factor Analysis revealed two factors, which were substantially correlated (r=0.43-0.80). All scale scores covered a broad range of the questionnaire's scaling range (0-100). The mean SRI-SS score was 52+/-17 indicating a homogenous scaling distribution.

Conclusion: The SRI is a multidimensional and highly specific tool with high psychometric properties for HRQL assessment in COPD patients with severe chronic respiratory failure.

Publication types

  • Validation Study

MeSH terms

  • Chronic Disease
  • Health Status
  • Health Status Indicators
  • Home Care Services
  • Humans
  • Middle Aged
  • Oxygen Inhalation Therapy
  • Positive-Pressure Respiration
  • Psychometrics / methods
  • Psychometrics / standards*
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / psychology*
  • Quality of Life*
  • Reproducibility of Results
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / psychology*
  • Respiratory Insufficiency / therapy
  • Surveys and Questionnaires / standards*