Management of steroid sensitive nephrotic syndrome: revised guidelines

Indian Pediatr. 2008 Mar;45(3):203-14.


Justification: In 2001, the Indian Pediatric Nephrology Group formulated guidelines for management of patients with steroid sensitive nephrotic syndrome. In view of emerging scientific evidence, it was felt necessary to review the existing recommendations.

Process: Following a preliminary meeting in March 2007, a draft statement was prepared and circulated among pediatric nephrologists in the country to arrive at a consensus on the evaluation and management of these patients.

Objectives: To revise and formulate recommendations for management of steroid sensitive nephrotic syndrome.

Recommendations: The need for adequate cortico-steroid therapy at the initial episode is emphasized. Guidelines regarding the initial evaluation, indications for renal biopsy and referral to a pediatric nephrologist are updated. It is proposed that patients with frequently relapsing nephrotic syndrome should, at the first instance, be treated with long-term, alternate-day prednisolone. The indications for use of alternative immunosuppressive agents, including levamisole, cyclophosphamide, mycophenolate mofetil and cyclosporin are outlined. The principles of dietary therapy, management of edema, and prevention and management of complications related to nephrotic syndrome are described. These guidelines, formulated on basis of current best practice, are aimed to familiarize physicians regarding management of children with steroid sensitive nephrotic syndrome.

Publication types

  • Practice Guideline
  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Glucocorticoids / therapeutic use*
  • Humans
  • Levamisole / therapeutic use
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use
  • Nephrotic Syndrome / drug therapy*
  • Nutritional Status
  • Prednisolone / therapeutic use*
  • Prednisone / therapeutic use*
  • Recurrence
  • Treatment Failure


  • Adjuvants, Immunologic
  • Glucocorticoids
  • Levamisole
  • Cyclophosphamide
  • Prednisolone
  • Mycophenolic Acid
  • Prednisone